表没食子儿茶素没食子酸酯在皮肤光老化炎症反应中的研究进展

Development of epigallocatechin gallate in the inflammatory response of skin photoaging

中文关键词:  表没食子儿茶素没食子酸酯  光老化  炎症

英文关键词:epigallocatechin gallate  photoaging  inflammation

中文摘要:

      皮肤吸收过量紫外线后引起的红肿、晒斑、皱纹等一系列现象被称为皮肤光老化。表没食子儿茶素没食子酸酯(epigallocatechin gallate, EGCG)作为茶叶中主要的活性成分, 除具有抗氧化、抗突变和抑制肿瘤形成和迁移的作用外, 在抗炎方面也有着显著作用。研究表明在紫外线引起的皮肤炎症反应中EGCG可以通过直接(清除炎症小体和炎症标记物)和间接[抑制核因子κB(nuclear factor kappa-B, NF-κB)、肿瘤坏死因子-α(tumor necrosis factor-α, TNF-α)等炎症信号转导通路]的方式保护皮肤细胞免受炎症损伤; 此外EGCG还可以通过抑制诱导型一氧化氮合酶基因(inducible nitric oxide synthase gene, iNOS)的表达和NO的生成, 减轻NO引起的炎症反应。本文综述了EGCG在皮肤光老化中炎症反应的防治效果和作用机制, 以期为深入开发抗皮肤光老化的功能产品提供实验依据和理论基础

英文摘要:

      A series of phenomena, such as redness and swelling, sunburn, wrinkles caused by the skin absorption of excessive UV light, are called skin photoaging. EGCG, as the main active ingredient in tea, exhibited significant anti-inflammatory effects in addition to its antioxidant, antimutagenic, and inhibitory effects on tumor formation and migration. Studies have shown that EGCG can protect skin cells from inflammatory damage in both direct (scavenging inflammasomes and inflammatory markers) and indirect ways [nuclear factor kappa-B(NF-κB), tumor necrosis factor-α (TNF-α) and other inflammatory signal transduction pathways] during the UV induced skin inflammatory response. In addition EGCG could also attenuate no induced inflammatory response by inhibiting the expression of inducible nitric oxide synthase gene (iNOS) and the production of NO. This paper reviewed the effect and mechanism of EGCG in the prevention and treatment of inflammation in skin photoaging. In order to provide experimental basis and theoretical basis for the further development of anti-skin photoaging functional products.