2018—2019年浙江省养殖水产品中6种喹诺酮类药物残留分析及风险评估

Analysis and risk assessment of 6 quinolones residues in aquatic products in Zhejiang province from 2018 to 2019

中文关键词:  喹诺酮类  养殖水产品  浙江省  残留分析  风险评估

英文关键词:quinolones  aquatic product  Zhejiang province  residue analysis, risk assessment

中文摘要:

      目的 评估2018—2019年浙江省养殖水产品中6种喹诺酮类药物残留分析及风险。方法 2018—2019年随机抽检浙江省11个地市658家养殖场的养殖水产品, 采用液相色谱-串联质谱法对水产品中恩诺沙星、环丙沙星、氧氟沙星、诺氟沙星、培氟沙星、洛美沙星6种喹诺酮类药物残留进行分析, 同位素内标法定量计算得到喹诺酮类药物残留量范围, 并通过查阅文献与每日允许摄入量对比, 得到人体实际每日摄入量范围。结果 6种喹诺酮类药物检出率为0~24.2%, 残留量范围为0~964 μg/kg; 其中鱼类样品检出残留量值最高, 达964 μg/kg; 龟鳖类样品检出药物种类最多, 达4种; 蛙类超标率最高达18.2%; 地市中湖州市养殖场6种药物的检出率最高, 达29.6%。食用风险评价以每人日摄入75 g水产品为例, 恩诺沙星摄入量范围为0.58~115.73 μg, 占每日最大允许摄入量的0.16%~31.11%。结论 浙江省养殖水产品中喹诺酮类药物有一定量的检出, 以限用药恩诺沙星、环丙沙星为主, 健康风险较小, 处于相对安全水平; 氧氟沙星、诺氟沙星、培氟沙星和洛美沙星4种禁用药物检出率较低, 但在个别样品中残留含量较高, 其每日最大允许摄入量尚不明确, 存在潜在危害性。

英文摘要:

      Objective To evaluate the analysis and risk of six quinolones residues in aquaculture products in Zhejiang province from 2018 to 2019. Methods Aquatic products in 658 aquafarms of 11 region in Zhejiang province were sampled from 2018 to 2019, and enrofloxacin, ciprofloxacin, ofloxacin, norfloxacin, pefloxacin and lomefloxacin were detected. Liquid chromatography-tandem mass spectrometry was used for detection, and the residual range of quinolones was calculated by isotopic internal standard method. The actual daily intake range was obtained by comparing the literature with the maximum allowable daily intake. Results The detection rates of 6 quinolones in aquatic products were 0?24.2%, and the residue were 0?964 μg/kg. The residue of fish samples was highest up to 964 μg/kg, and the kinds of residues detected in turtle samples were the most up to 4, the highest exceeding standard rate was 18.2% in frog samples. The detection rate of the 6 quinolones in aquafarms in Huzhou was the highest up to 29.6%. Taking 75 g of aquatic products per person per day as an example, the intake of enrofloxacin ranged from 0.58 μg to 115.73 μg, accounting for 0.16% to 31.11% of the maximum allowable daily intake. Conclusion A certain amount of quinolones is detected in aquaculture aquatic products in Zhejiang province, mainly limited to enrofloxacin and ciprofloxacin, with low health risk and relatively safe level. The detection rates of ofloxacin, norfloxacin, pefloxacin and lomefloxacin are low, but the residual contents in individual samples are high, and the maximum allowable daily intake are not clear, which have potential hazards.