鱼源硫酸软骨素的研究进展

Research progress of fish-derived chondroitin sulfate

中文关键词:  鱼源硫酸软骨素  结构  制备工艺  生物活性

英文关键词:fish-derived chondroitin sulfate  structure  preparation process  biological activity

中文摘要:

      鱼源硫酸软骨素是从鱼体中提取的一类硫酸化链状粘性多糖，主要由N-乙酰-D-氨基半乳糖和葡糖醛酸通过β-1,3糖苷键重复连接而成，一般含有50~70个二糖单位，是一种结构复杂、功能多样的药用生物大分子。近几年研究发现鱼源硫酸软骨素不仅具有抗炎活性，还具有抗肿瘤、调节血脂、抗凝血和血栓、抗氧化和调节神经生长等多种生物活性，广泛应用于食品工业、生物、制药、医学、化妆品和材料等领域。本文阐述了鱼源硫酸软骨素的结构、提取纯化工艺、生物活性及应用，并对其发展前景进行了展望，旨在为鱼源硫酸软骨素进一步的研究与开发提供参考。

英文摘要:

      Fish-derived chondroitin sulfate is a type of sulfated viscous polysaccharide extracted from fish. It is mainly composed of N-acetyl-D-galactosamine hydrateand glucuronic acid repeatedly connected by β-1,3 glycosidic bonds, generally containing 50–70 disaccharide units, which is a kind of medicinal biological macromolecule with complex structure and diverse functions. In recent years, studies have found that fish-derived chondroitin sulfate not only has anti-inflammatory activity, but also has various biological activities such as anti-tumor, regulating blood lipids, anti-coagulation and thrombosis, anti-oxidation and regulating nerve growth. It is widely used in the fields of food industry, biology, pharmaceuticals, medicine, cosmetics and materials. This article described the structure, extraction and purification process, biological activity and application of fish-derived chondroitin sulfate, and prospected its development prospects, aiming to provide a reference for the further research and development of fish-derived chondroitin sulfate.