致病性弧菌及其噬菌体防治研究进展

Review on pathogenic Vibrio and its phage control

中文关键词:  致病性弧菌  噬菌体  预防和治疗

英文关键词:pathogenic Vibrio  phage  prevention and treatment

中文摘要:

      近年来, 水产养殖业迅速发展, 作为人类和海洋动物的重要病原微生物之一的致病性弧菌越来越受到人们的关注。随着抗生素的大量使用, 细菌耐药、超级细菌、药物残留等问题的出现, 噬菌体疗法、生物制剂等生物抑菌方法得到广大研究者们的青睐。噬菌体对细菌病的治疗和预防均具有一定的作用。但是仍需要解决若干科学和技术问题后才能提供安全、可靠、可重复且具有商业潜力的方法。本文概述了海洋生态系统中弧菌的分布和生存特点, 总结了对人类和水产动物致病的主要弧菌种类、致病特性、致病机制和防治现状, 以及噬菌体在防控水产品中致病性弧菌的研究现状, 并分析了噬菌体治疗的优缺点, 以期为噬菌体在水产品的防治和相关食品安全领域中的进一步应用提供参考。

英文摘要:

      In recent years, the aquaculture industry has developed rapidly. As one of the important pathogenic microorganisms of humans and marine animals, pathogenic Vibrio has attracted more and more attention. With the extensive use of antibiotics, the emergence of problems such as bacterial resistance, super bacteria, drug residues, etc., biological antibacterial methods such as phage therapy and biological agents have been favored by the majority of researchers. Bacteriophages have a certain effect on the treatment and prevention of bacterial diseases. However, a number of scientific and technical issues still need to be resolved before a safe, reliable, repeatable, and commercially potential method can be provided. This article summarized the division and survival characteristics of Vibrio in marine ecosystems, summarized the main types, pathogenic characteristics, pathogenic mechanism and control status of Vibrio which are pathogenic to humans and aquatic animals. It reviewed the research status of bacteriophages in the prevention and control of pathogenic Vibrio in aquatic products, and analyzed the advantages and disadvantages of phage therapy, so as to provide reference for the further application of phage in the prevention and control of aquatic products and related food safety fields.