杏仁肽对高脂血症大鼠辅助降血脂的功能研究

Auxiliary hypolipidemic effect of almond peptides on rats with hyperlipidemia

中文关键词:  杏仁肽  高脂血症  降血脂

英文关键词:almond peptides  hyperlipidemia  hypolipidemic

中文摘要:

      目的 探究杏仁肽对高脂血症模型大鼠的降血脂作用。方法 采用高脂饲料形成大鼠混合型高脂血症动物模型, 将健康雄性40只SD大鼠随机分为5组, 分别为空白对照组、高脂血症模型组和杏仁肽低、中、高剂量组(0.4、0.8和1.6 g/kg BW)。空白对照组每日给予维持饲料, 其余各组每日给予高脂饲料。连续经口给予受试物30 d, 测定大鼠血清总胆固醇(total cholesterol, TC)、甘油三酯(triglycerides, TG)、高密度脂蛋白胆固醇(high-density lipoprotein cholesterol, HDL-C)和低密度脂蛋白(low-density lipoprotein cholesterol, LDL-C)含量。结果 模型对照组和空白对照组比较, 大鼠血清TG、TC及LDL-C水平升高, 差异均有统计学意义(P<0.05), 判定混合型高脂血症动物模型成立。与模型对照组比较, 杏仁肽低剂量组血清TC降低, 差异具有统计学意义(P<0.05), 同时杏仁肽各剂量组血清TG水平不显著高于模型对照组(P>0.05), 杏仁肽各剂量组血清HDL-C水平不显著低于模型对照组(P>0.05)。结论 在一定剂量下, 杏仁肽具有辅助降血脂功能。

英文摘要:

      Objective To investigate the hypolipidemic effect of almond peptides on hyperlipidemia model of rats. Methods A high-fat diet was used to form a mixed animal model of hyperlipidemia in rats, and 40 healthy male SD rats were randomly divided into 5 groups, namely blank control group, hyperlipidemia model group and low dose, medium dose and high dose of almond peptides groups (0.4, 0.8 and 1.6 g/kg BW, respectively). The blank control group was given maintenance feed and the remaining groups were given high-fat diet daily. After the corresponding test substance was continuously administered orally for 30 days, the level of serum total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) were determined in rats. Results The serum TG, TC and LDL-C levels of the rats in the model control group significantly increased than the blank control group (P<0.05), suggesting the mixed hyperlipidemia animal model was established. The serum TC level significantly decreased in the low-dose of almond peptides group than the model control, the differences were statistically significant (P<0.05), and the serum TG level in each dose of almond peptides groups did not significantly decreased than the model control group (P>0.05). The serum HDL-C level of in each dose of almond peptides groups did not significantly declined than the model control group (P>0.05). Conclusion At a certain dose, almond peptides have an auxiliary effect of reducing blood lipid.