氧化应激参与丙烯酰胺致神经细胞凋亡及炎症反应的研究进展

Research progress on the effect of oxidative stress on acrylamide-induced neuronal apoptosis and inflammatory response

中文关键词:  丙烯酰胺  神经毒性  氧化应激  凋亡  炎症

英文关键词:acrylamide  neurotoxicity  oxidative stress  apoptosis  inflammation

中文摘要:

      丙烯酰胺(acrylamide, AA)是一种重要的工业原料, 具有神经毒性、生殖毒性、遗传毒性及潜在致癌性。AA作为美拉德反应的副产物之一, 在油炸和焙烤等热加工高淀粉食品中广泛存在。氧化应激(oxidative stress, OS)是机体内氧化与抗氧化系统之间的平衡被破坏而造成的应激状态, 可被多种环境因素激活, 并与细胞凋亡及炎症反应的发生密切相关。大量研究发现, OS常伴随着AA诱导的中枢神经系统细胞凋亡及炎症反应发生, 也是AA与神经退行性疾病相关性的重要连接纽带。本文就OS在AA诱导的凋亡及炎症反应中的作用进行综述, 为AA神经毒性机制的深入研究及其毒性干预提供参考。

英文摘要:

      Acrylamide (AA) is a critical material in chemical industry, which has neurotoxicity, reproductive toxicity, genotoxicity, and potential carcinogenicity. As one of the by-products of Maillard reaction, AA is widely formed in starchy food products during cooking at high-temperatures, such as frying and baking. Oxidative stress (OS) is a state of stress caused by the destruction of the balance between the oxidation and antioxidant systems in the body, which can be activated by various environmental factors, and is closely related to the occurrence of apoptosis and inflammation. A large number of studies have shown that OS often occurs accompanied by apoptotic and inflammatory reactions and it is also an important link between AA and neurodegenerative diseases. This article reviewed the role of oxidative stress in AA-induced apoptosis and inflammation in the central nervous system, and provided theoretical reference on the further study of AA neurotoxicity mechanism and its toxic intervention.