电感耦合等离子体质谱法测定薄膜包衣粉中的总砷含量

Determination of total arsenic in film coating powder by inductively coupled plasma mass spectrometry

中文关键词:  电感耦合等离子体质谱法  薄膜包衣粉  总砷

英文关键词:inductively coupled plasma mass spectrometry  film coating powder  total arsenic

中文摘要:

      目的 建立电感耦合等离子体质谱法(inductively coupled plasma mass spectrometry, ICP-MS)检测薄膜包衣粉中总砷含量的分析方法。方法 样品经过混合酸(硝酸:硫酸=10:1, V:V)在石墨消解仪上120 ℃预消解20 min, 再进行微波消解。赶酸后, 以500 μg/L锗作为内标物质, 以氦气作为反应气, 采用ICP-MS进行检测。结果 砷在浓度2.0~40.0 μg/L之间呈现良好的线性关系(r2=0.9999), 该方法检出限为0.0054 mg/kg, 定量限为0.018 mg/kg, 平均回收率为94.40%~101.40%, 重复性实验精密度为0.65%。结论 该方法操作简便、重现性好、灵敏度高、准确, 适合测定薄膜包衣粉中的总砷。

英文摘要:

      Objective To establish a method for the determination of total arsenic in film coated powder by inductively coupled plasma mass spectrometry (ICP-MS). Methods The sample was pre-digested on a graphite digestion apparatus at 120 ℃ for 20 minutes with mixed acid (nitric acid: sulfuric acid=10:1, V:V), and then microwave digestion was performed. After acid removal, 500 μg /L germanium was used as internal standard and helium as reaction gas and ICP-MS was used for detection. Results Arsenic showed a good linear relationship between the concentration of 2.0?40.0 μg/mL (r2=0.9999), the limit of detection was 0.0054 mg/kg, and the limit of quantification was 0.018 mg/kg. The average recovery was 94.40%?101.40%, and the precision of repeatability test was 0.65%. Conclusion This method is easy to operate, and has good reproducibility, high sensitivity and accuracy, which is suitable for the determination of arsenic in film coating powder.