鱼油提取物磷脂片制剂工艺研究

Study on preparation technology of fish oil and extract phospholipid tablets

中文关键词:  鱼油  磷脂  制剂工艺  微晶纤维素  二氧化硅

英文关键词:fish oil  phospholipid  preparation process  microcrystalline cellulose  silica

中文摘要:

      目的 研究鱼油提取物磷脂片配方及制剂的工艺方法。方法 通过筛选辅料、填充剂、崩解剂、吸附剂对鱼油提取物磷脂片的成型工艺进行研究, 并通过比较制粒结果、崩解时限结果以及脆碎度结果, 对配方进行优化。结果 通过对比实验分析出优选磷酸氢钙、微晶纤维素、二氧化硅等为主要辅料, 可提高产品可压性及崩解效果。经检测片剂硬度可达到15.6~20.6 kg/cm2, 检测产品的脆碎度＜0.5%,符合产品质量要求。 结论 本研究优选的制剂方法稳定可行, 为鱼油提取物磷脂片制备工艺的确定及生产的控制提供了科学的实验依据, 同时为油脂类物料制成片剂的制备工艺提供参考依据。

英文摘要:

      Objective To study the formulation and preparation process of fish oil and extract phospholipid tablets. Methods The processing technology of fish oil and extract phospholipid tablets was studied by selecting excipients, fillers, disintegrants and adsorbents, and the formulation was optimized by comparing the results of granulation, disintegration time limit and fragility. Results Through comparative test, it was found that the main auxiliary materials, such as calcium hydrogen phosphate, microcrystalline cellulose and silica, could improve the compressibility and disintegration effect of the product. The hardness of the tested wafers could reach 15.6– 20.6 kg/cm2, and the brittle degree of the tested products was less than 0.5%, in line with product quality. Conclusion The optimized preparation method is stable and feasible, which provides scientific experimental basis for the determination of preparation technology and production control of fish oil and extract phospholipid tablets, and provides reference for the preparation technology of tablets made of oil materials.