酚类化合物的吸收特性及对肠道菌群的作用

Absorption characteristics of phenolic compounds and effects on intestinal flora

中文关键词:  酚类化合物  生物活性  吸收  肠道菌群

英文关键词:phenolic compounds  bioactivity  absorption  intestinal flora

中文摘要:

      作为常见的植物次生代谢产物, 酚类化合物在果蔬、谷物、茶、咖啡等植物性农产品、食品和饮料中广泛存在。酚类已被证明具有多种生物活性, 包括调节血糖血脂、抗肿瘤、抗菌、抗病毒、调节肠道微生态等。酚类复杂混合物的生物利用度与其吸收特性密切相关。本文综述了酚类在消化道小肠和结肠段的吸收规律, 总结了肠道菌群在消化过程中的作用, 并介绍了近年来酚类对肠道菌群调节研究的进展。膳食酚类复杂多样, 与肠道菌群相互作用并相互影响, 且这一过程存在个体差异, 因此酚类的吸收和作用机制研究仍处于起步阶段, 未来可借助宏基因组、转录组、蛋白质组以及高通量代谢组学的发展来不断推进本领域的理论研究。

英文摘要:

      As a common plant secondary metabolite, phenol compounds are widely present in vegetable agricultural products such as fruits and vegetables, cereals, tea, coffee, etc., as well as in foods and beverages. Phenols have been shown to have a variety of biological activities, including regulating blood glucose and lipids, antitumor, antibacterial, antiviral, and regulating intestinal micro ecology. The bioavailability of various complex mixtures of food introduced phenols is closely related to its absorption characteristics. This article reviewed the absorption patterns of phenols in the small intestine and colon, summarized the roles of the intestinal flora in the digestive process, and introduced the recent research progresses on phenols' regulation roles of intestinal flora. Dietary phenols are complex and diverse, and they interact with intestinal flora and influence each other mutually, which is a individualized procedure. Therefore, research on the absorption and action mechanism of phenols is still in very early stages. With the development of met genomics, transcriptomes, proteome and metabolomics, the theoretical research about phenols' absorption and bioactive mechanism will be promoted in the future.