PPAR-γ及其调节剂与脂肪代谢的关系研究进展

Research progress on the relationship between PPAR-γ with its agonists/antagonists and fat metabolism

中文关键词:  PPAR-γ  脂肪代谢  调控

英文关键词:PPAR-γ  fat metabolism  regulation

中文摘要:

      肥胖及其带来的高血压、糖尿病等一系列代谢性疾病已经为人们所关注。关于引起肥胖的机制已经有大量的报道, 过氧化物酶增殖物激活受体(peroxisome proliferator-activated receptors, PPARs)家族成员对肥胖及脂代谢调节作用的研究取得了一些进展, 过氧化物酶增殖物激活受体-γ(PPAR-γ)及其激活因子/抑制因子在脂肪代谢、各类炎症和免疫反应中发挥了极其重要的作用。本文介绍了PPAR-γ对脂肪形成过程中的调控作用, 以及PPAR-γ激动剂/拮抗剂与脂代谢的关系, 为深入研究PPAR家族在肥胖发生过程中的作用机制及控制措施提供参考。

英文摘要:

      Obesity and its related metabolic diseases such as hypertension and diabetes have attracted people's attention. There have been a lot of reports on the mechanism of obesity, and some studies on the regulation of obesity and lipid metabolism by peroxisome proliferator-activated receptors (PPARs) family members have made some progress. Peroxisome proliferator-activated receptor-gamma (PPAR-γ) and its activators/inhibitors play an extremely important role in fat metabolism, various types of inflammation and immune responses. This review described the regulation effects of PPAR-γ on the lipogenesis, and the relationship between PPAR-γ agonist/antagonist and lipid metabolism, in order to provide reference for further study of the mechanism and control measures of PPAR family in the obesity pathogenesis.