软胶囊化胶收率影响因素研究

Study on the factors influencing the yield of soft capsule

中文关键词:  化胶工艺  化胶罐  正交实验

英文关键词:glue melting process  the glue tank  orthogonal test

中文摘要:

      目的 确定影响软胶囊化胶收率的因素。方法 通过优化化胶的工艺流程, 采用控制变量法进行逐一排除, 优化化胶所需时间, 确定第1次抽真空时间、第2次抽真空时间、真空度大小是影响化胶收率的关键指标, 通过正交实验, 确定提高化胶收率的最佳组合。结果 经过实验验证, 投胶温度、煮胶时间、罐子搅拌桨速度是影响化胶出胶的时间的主要因素, 而第1次抽真空时间5 min、第2次抽真空时间10 min、真空度大小?0.070 MPa为提高化胶收率的最佳组合参数。结论 通过一系列的改善, 优化化胶流程, 缩短化胶所需时间, 并且通过一系列实验, 探索出提高化胶收率的最佳参数, 提高产品收率, 降低成本, 稳定产品质量。

英文摘要:

      Objective To determine the factors affecting the yield of soft capsule. Methods By optimizing the technological process of the glue and using the control variable method to eliminate them one by one, the time needed for the glue was optimized, and the first vacuum extraction time, the second vacuum extraction time and the vacuum degree were determined to be the key indexes affecting the yield of the glue. Through the orthogonal experiment, the optimal combination for improving the yield of the glue was determined. Results It was verified by experiments that the temperature of glue casting, the time of glue boiling and the speed of single stirring paddle in the pot were the influences of the time of the glue melting and the glue releasing. The best combination parameters were 5 min for the first vacuum extraction, 10 min for the second vacuum extraction and ?0.070 MPa for the vacuum degree. Conclusion Through a series of improvements, the process of gelatinization is optimized to shorten the time needed for gelatinization. In addition, through a series of experiments, the optimal parameters for improving the yield of gelatinization are explored to improve the yield of products, reduce costs and stabilize product quality.