超高效液相色谱-串联质谱法测定婴幼儿化妆品中米诺地尔等7种成分

Determination of minoxidil and other 6 kinds of components in infant cosmetics by ultra-high performance liquid chromatography-tandem mass spectrometry

中文关键词:  米诺地尔  氢化可的松  螺内酯  雌酮  坎利酮  醋酸曲安奈德  黄体酮  婴幼儿化妆品  超高效液相色谱-串联质谱法

英文关键词:minoxidil  hydrocortisone  spironolactone  estrone  canalidone  triamcinolone acetate  progesterone  infant cosmetics  ultra-high performance liquid chromatography-tandem mass spectrometry

中文摘要:

      目的 对市售婴幼儿化妆品中米诺地尔、氢化可的松、螺内酯、雌酮、坎利酮、醋酸曲安奈德、黄体酮7种禁用成分进行市场调研。方法 以Atlantis dC18 (100 mm×2.1 mm, 2 μm)为分析柱, 0.1%甲酸溶液-甲醇为流动相进行梯度洗脱后, 采用超高效液相色谱-串联质谱电喷雾电离(ESI+)检测7种禁用成分。结果 7种 标准溶液在10~600 ng浓度范围内呈良好线性关系(r≥0.9990), 加标回收率为92.6%~95.2%, 相对标准偏差(relative standard deviations, RSDs)为2.1%~4.1%, 对20批市售婴幼儿化妆品中米诺地尔等7种成分进行检测, 结果均未检出。结论 我省婴幼儿化妆品市场中米诺地尔等7种成分的市场现状相对良好。

英文摘要:

      Objective To investigate 7 kinds of banned ingredients (minoxidil, hydrocortisone, spironolactone, estrone, canalidone, triamcinolone acetate, and progesterone) in infant cosmetics on the market. Methods Seven kinds of banned ingredients were detected by ultra-high performance liquid chromatography-tandem mass spectrometry electrospray ionization (ESI+), using a column of Atlantis dC18 (100 mm×2.1 mm, 2 μm), with the mobile phase of 0.1% formic acid solution for gradient elution. Results The 7 standard solutions showed good linear relationships (r≥0.9990) in the concentration range of 10-600 ng. The recoveries of the spiked concentrations were 92.6%-95.2% and relative standard deviations (RSDs) were 2.1%-4.1%. The 7 components in 20 batches of cosmetics for infants and young children were not detected. Conclusion The market situation of minoxidil and other 6 ingredients in infant cosmetics market in our province is relatively good.