牛磺酸影响脂肪代谢的研究概况

Research progress of the effect of taurine on fatty metabolism

中文关键词:  牛磺酸  甘油三酯  肥胖  脂肪肝

英文关键词:taurine  triglyceride  obesity  fatty liver

中文摘要:

      牛磺酸是一种广泛存在于哺乳动物组织中的小分子含硫氨基酸,结构简单且不参与蛋白质合成,牛磺酸可由甲硫氨酸和半胱氨酸合成,也可以由饮食提供,富含于鱼贝类等海产品中,具有多种生理功能。动物实验和临床实验表明牛磺酸可显著改善肥胖,降低血清甘油三酯水平,减少肝脏脂肪蓄积。本文从动物实验、细胞实验、临床实验和流行病学调查四个方面总结了牛磺酸对脂肪代谢的影响,并主要从促进脂肪分解代谢、抑制脂肪合成、减少炎症反应和氧化应激、提高脂联素水平、与胆汁酸结合等方面归纳了牛磺酸影响脂肪代谢的作用机理,为进一步研究牛磺酸促进脂肪代谢的作用机制提供参考,也为开发以牛磺酸为功能因子、具有减肥、改善血脂及脂肪肝功能的保健品提供理论依据。

英文摘要:

      Taurine is a small molecule of sulfur-containing amino acid that is widespread in mammalian tissues and has many physiological functions. Taurine can be synthesized from methionine and cysteine, and it is rich in seafood such as fish and shellfish. Animal experiments and clinical trials have shown that taurine could significantly improve obesity, reduce serum triglyceride and hepatic fat accumulation. The present paper summarized the effect of taurine on fatty metabolism from four aspects: animal experiments, cell experiments, clinical trials and epidemiological investigation. The mechanism of taurine promoting fatty metabolism was summarized from the aspects of promoting lipolysis, inhibiting triglyceride synthesis, reducing inflammatory reaction and oxidative stress, improving adiponectin level and combining with bile acid, which provided the basis for the further study on taurine nutrition and its development and utilization in functional food.