食源性动物组织中β-受体激动剂研究进展

Research progress on β-agonists in food-borne animal tissues

中文关键词:  β-受体激动剂  代谢消除规律  食源性动物组织  分析技术

英文关键词:β-agonists  metabolic elimination rule  food-borne animal tissues  analysis technologies

中文摘要:

      β-受体激动剂是一类苯乙醇胺类药物, 化学结构和生理功能类似于肾上腺素和去甲肾上腺素, 常用于防治人和动物支气管哮喘等疾病。由于β-受体激动剂类药物可促进动物体内蛋白质合成并抑制脂肪沉淀, 使动物体内营养成分再分配, 所以此类药物常被添加到动物饲养过程中用于提高瘦肉率, 继而造成药物在动物体内残留, 人类食用后会引发急性中毒而威胁健康。虽然大多数国家已经明令禁止在动物饲养中使用此类药物, 但是仍然存在非法使用的情况。为了加强动物源性食品安全, 各国已经展开了对β-受体激动剂类药物的研究, 已建立多种快速准确的检测方法。本研究主要对β-受体激动剂的结构和性质、在动物源性食品中代谢消除规律和β-受体激动剂检测技术3个方面进行阐述, 并对β-受体激动剂药物残留检测的未来研究方向进行展望。

英文摘要:

      β-agonists are a class of phenylethanolamines with chemical structures and physiological functions similar to epinephrine and norepinephrine. They are commonly used to prevent diseases such as bronchial asthma in humans and animals. Since β-agonists can promote protein synthesis and inhibit fat deposition in animals, and redistribute nutrients in animals, such drugs are often added to animal feeding processes to increase lean meat rate, which in turn leads to drugs residue in animals, causing acute poisoning and threatening health after human consumption. Although most countries have explicitly banned the use of such drugs in animal husbandry, there are still cases of illegal use. In order to enhance the safety of animal-derived foods, countries have begun research on β-agonist agonists, and a variety of rapid and accurate detection methods have been established. This article summarized the structure and properties, the metabolic elimination rule in animal-derived foods and the detection technology of β-agonists, and prospected the future research direction of β-agonist drug residue detection.