儿茶素类化合物抑菌作用及其作用机制的研究进展

Research progress of antibacterial effects of catechins and its mechanism

中文关键词:  儿茶素类化合物  抑菌作用  协同作用  作用机制

英文关键词:catechins  antibacterial activity  structure-activity relationship  mechanism

中文摘要:

      儿茶素类化合物能直接抑制多种菌株的生长, 也可以与抗生素产生良好的协同作用, 增强其抗菌作用, 调节细菌对抗生素的耐药性。酯型儿茶素与简单儿茶素的抑菌效果差异显著, 分子结构影响儿茶素类化合物的抑菌效果。儿茶素类化合物可与细胞膜组成成分相互作用, 改变细胞膜的物理特性, 造成细胞内容物渗漏; 调控相关基因, 控制蛋白质表达, 影响细胞正常代谢; 产生活性氧并造成胞内外氧化应激, 导致生物大分子受到氧化损伤。儿茶素类化合物具有良好的抑菌效果、增敏作用, 在食品与医药行业具有较大的研究价值和应用前景。本文对儿茶素的抑菌作用及其机制进行综述。

英文摘要:

      Catechins can directly inhibit the growth of a variety of strains, produce good synergistic effects with antibiotics, enhance their antibacterial activity, and also regulate the resistance of bacteria to antibiotics. The inhibitory effects of esterified-catechins and simple catechins were different, and the molecular structures influenced the antibacterial effects of catechin compounds. Researches indicated that catechins were able to modulate the structure and function of membranes through the molecular interaction taking place between membrane phospholipids and catechin molecules. A significant leakage was observed when catechins were used. Catechins had metabolic effects and modulate the expression of relevant genes. Catechins could also function as a prooxidant, produce reactive oxygen species, and induce oxidative stress-related responses, leading to the oxidative damage to biological macromolecules such as proteins, DNA, and phospholipids. The good bactericidal activity and antibacterial activity for potentiating the effects of certain antibiotics showed that catechins had a possibility to apply to the fields of food and pharmaceuticals. In this paper, the antibacterial activity of catechins and its mechanism were reviewed.