电感耦合等离子体质谱法在药品元素检测中的应用

Application of inductively coupled plasma mass spectrometry in drug elemental analysis

中文关键词:  药品  元素  重金属  电感耦合等离子体质谱法

英文关键词:drug  element  heavy metal  inductively coupled plasma mass spectrometry

中文摘要:

      药品及药品原料中含有的重金属及有害元素如砷、汞、铅、铬、镉等会对身体产生很大的毒副作用, 而药品及药品原料中含有的必需微量元素及矿物质元素如铁、铜、锌、锰、硒、硅等摄入过量、不足也会不同程度引起人体生理的异常。因此, 药品中元素检测对于药品质量控制具有重要的意义。常见药品中元素的检测方法有原子吸收光谱法、电感耦合等离子体发射光谱法、原子荧光光谱法、比色法、电感耦合等离子体质谱法等。本文对电感耦合等离子体质谱法在药品检测中的应用包括重金属及有害元素检测、微量及矿质元素检测、常规元素检测、同位素元素检测、元素形态检测进行了探讨。结果表明, 电感耦合等离子体法用于药品的元素检测时, 线性关系、精密度、检出限和回收率都符合检测需求。电感耦合等离子体质谱法检出限低, 线性范围宽, 可实现多元素同时测定和同位素元素检测, 且与其他分离设备联用可用于元素形态分析, 因此被广泛应用于药品的元素检测。

英文摘要:

      Heavy metals and harmful metals in drugs and pharmaceutical raw materials such as As, Hg, Pb, Cr, Cd, etc. do harm to human health, while the excessive or insufficient intake of microelements and mineral elements in drugs and pharmaceutical raw materials such as Fe, Cu, Zn, Mn, Se, Si, etc. can cause different levels of human physiological abnormalities. Therefore, it is important to detect elements in drugs for quality control. Atomic absorption spectrometry, inductively coupled plasma spectrometry, atomic fluoresce spectrometry, colorimetry and inductively coupled plasma mass spectrometry (ICP-MS) are common detection methods of elements. The article summarized the applications of ICP-MS in drug testing, such as heavy metals and harmful metals, microelements and mineral elements, conventional elements, isotopic elements, and element speciation test. The results showed that the liner relationships, precisions, detection limits and recoveries could meet the detect requirements completely. Due to low detection limit, wide linear range, multi-element determination and isotope detection at the same time, and accomplishment of element speciation analysis when combined with other separation equipments, ICP-MS has been widely applied in the detection of elements in drugs.