微波消解-电感耦合等离子体质谱法同时测定 药食两用中药材中的15种元素

Simultaneous determination of 15 elements in Chinese herbal medicines with both food and medicine by inductively coupled plasma mass spectrometry

中文关键词:  药食两用中药材  电感耦合等离子体质谱法  元素  微波消解

英文关键词:Chinese herbal medicines with both food and medicine  inductively coupled plasma mass spectrometry  elements  microwave digestion

中文摘要:

      目的 建立电感耦合等离子体质谱(ICP-MS)法同时测定药食两用中药材中镁、铝、铬、锰、铁、钴、镍、铜、锌、砷、镉、钡、汞、铅和铀15种元素的含量。方法 以硝酸:盐酸(V:V=4:1)为消解试剂, 采用微波消解法进行样品前处理, 在线加入内标并开启碰撞反应池。对该方法的检出限、线性范围、精密度和回收率进行考察, 并对10种药食两用中药材中15种元素进行同时测定。结果 15种元素线性关系良好, 相关系数均大于0.999, 检出限为0.003~1.998 mg/kg, 方法重复性相对偏差均小于19.1%, 回收率在79.35%~112.96%范围之间。结论 该方法快速、灵敏, 可同时准确测定药食两用中药材中多元素。

英文摘要:

      Objective To determine 15 elements, including Mg, Al, Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Cd, Ba, Hg, Pb, and U in 10 kinds of Chinese herbal medicines with both food and medicine by inductively coupled plasma mass spectrometry (ICP-MS). Methods Samples were digested by nitric acid: hydrochloric acid (V:V=4:1) with microwave. Online internal standard was added and opened collision cell in combination with ICP-MS. The limits of detection, linear ranges, recoveries and relative standard deviations (RSDs) of this method were analyzed. The content of 15 elements in 10 kinds of Chinese herbal medicines with both food and medicine were simultaneously determined. Results Fifteen elements had good linear relationships with the correlation coefficients > 0.999, and the limits of detection were 0.003~1.998 mg/kg. The RSDs of repeatability for 15 elements were all less than 19.1%, and the recoveries were in the range of 79.35%~112.96%, respectively. Conclusion The proposed method is rapid, sensitive and accurate, which can meet the detection requirements of multi-element in Chinese herbal medicines with both food and medicine.