食品用纸杯中光引发剂特定迁移量的气相色谱- 串联质谱测定方法

Determination of the migration of photoinitiators from paper cup into food stimulants by gas chromatography-tandem mass spectrometry

中文关键词:  光引发剂  纸杯  食品模拟物  气相色谱-串联质谱法  固相萃取

英文关键词:photoinitiator  paper cup  food simulant  gas chromatography-tandem mass spectrometry  solid phase extraction

中文摘要:

      目的 建立11种光引发剂类化合物食品用纸杯特定迁移量的气相色谱-串联质谱(gas chromatography- tandem mass spectrometry, GC-MS/MS)检测方法。方法 食品模拟物中的光引发剂类化合物经反相固相萃取柱富集净化后, 采用中等级性的DM-17MS气相色谱柱进行分离; 采用三重四极质谱的多反应监测模式(multiple reaction monitoring, MRM)对化合物进行定量测定。结果 本方法可在17 min内完成11种目标化合物的色谱分离。11种光引发剂在低、中、高3个添加水平的回收率在65.0%~119.8%范围内, 相对标准偏差为1.2%~10.6% (n=6), 方法检出限为1~7 μg/L, 定量限为2~20 μg/L。结论 该方法灵敏度高, 定量准确, 适用于食品模拟物中光引发剂类物质特定迁移量的测定。

英文摘要:

      Objective To establish an analytical method for the determination of the migrants of 11 kinds of photoinitiator from paper cups into food simulants by gas chromatography-tandem mass spectrometric (GC-MS/MS). Methods The reverse-phased solid phase extraction cartridges were used for the extraction, enrichment and clean-up of the 11 kinds of potoinitiator from simulants. The analytes were separated on a moderately polar DM-17MS column, and subsequently determined by triple quadruple mass spectrometry operating under multiple reaction monitor (MRM) mode. Results The GC-MS/MS analysis was achieved within 17 min. The recoveries of the method were ranged from 65.0% to 119.8% for the 11 kinds of photoinitiator at 3 spiked levels, and the relative standard deviations were between 1.2% and 10.6%. The limits of detection (LOD) and the limits of quantification (LOQ) were 1~7 μg/L and 2~20 μg/L, respectively. Conclusion The established method has been validated to be sensitive and accurate, which is applicable to the analysis of migrants of photoinitiators in food simulants.