酪蛋白水解物与γ-氨基丁酸复配制剂 改善睡眠功能的研究

Study on improvement of sleep function by the compound of casein hydrolysate and γ-aminobutyric acid

中文关键词:  酪蛋白水解物  γ-氨基丁酸  改善睡眠

英文关键词:casein hydrolysate  γ-aminobutyric acid  sleeping quality improvement

中文摘要:

      目的 研究酪蛋白水解物与γ-氨基丁酸的复配制剂对小鼠改善睡眠功能的作用研究。方法 18~22 g健康雄性小鼠, 按体重随机分组。按照人体推荐剂量的5倍、10倍、30倍为低、中、高3个剂量, 即0.1、0.2和0.6 g/kg bw, 另设对照组。观察睡眠指标。结果 3个剂量组入睡动物数及睡眠时间均为0, 各剂量组动物入睡数与对照组进行比较, 差异均无统计学意义(P>0.05)。该制剂与对照组比较可延长中、高剂量组小鼠戊巴比妥钠催眠的时间(P<0.05), 可缩短巴比妥钠催眠的中、高剂量组小鼠的入睡潜伏期, 与对照组比较差异有统计学意义(P<0.05)。结论 根据《保健食品检验与评价技术规范》对改善睡眠保健食品的判定依据, 酪蛋白水解物与γ-氨基丁酸的复配制剂具有一定的改善睡眠作用。

英文摘要:

      Objective To study the improvement of the sleep function by the compound of casein hydrolysate and γ-aminobutyric acid on mice. Methods Healthy male mice with the body weight of 18~22g were divided into different groups randomly. According to the recommended dosage of 5 times, 10 times, 30 times, the mice were divided into low(0.1 g/kg bw), medium (0.2 g/kg bw)and high(0.6 g/kg bw) dose groups, and another control group was set, to observe the sleeping indexes of mice. Results The number of sleeping animals and sleep time of the 3 groups were 0, and the difference was not statistically significant (P>0.05)compared with the control group. Compared with the control group, the compound preparation of casein hydrolysate and γ-aminobutyric acid could prolonged the time of the sodiumin mice with middle and high dose group(P<0.05) and shorten the latency of sleep in the middle and high dose group of mice (P<0.05).Conclusion According to the judgment basis on improving the sleep health from "Technical specification for inspection and evaluation of health food", the compound preparation of casein hydrolysate and γ-aminobutyric acid can improve the sleep quality of mice.