乳糜泻研究进展

Recent advances in celiac disease

中文关键词:  乳糜泻  麸质蛋白  基因

英文关键词:celiac disease  gluten  genes

中文摘要:

      乳糜泻是一种遗传易感个体因摄入含麸质蛋白的谷物(小麦、大麦和祼麦)及其制品而诱发的慢性自身免疫性肠病, 影响着世界上约1%人口的健康, 并呈增长趋势; 在中国可能也存在乳糜泻“冰山”现象, 发生率远比原先预计的高; 然而目前, 中国从事医疗卫生和食品工业的专业人员对乳糜泻的认识仍存在不足。本文着重介绍了国内外在乳糜泻的流行病学、发病机制、临床症状、诊断和治疗等方面的研究进展。全面了解乳糜泻的相关知识, 提高对乳糜泻的意识, 有助于推动中国对乳糜泻的预防和控制, 促进无麸质食品的开发和研究。

英文摘要:

      Celiac disease (CD) is a chronic autoimmune enteropathy elicited in genetically predisposed individuals by exposure to containing gluten-containing grains (i.e., wheat, barley, and rye), which is affecting about 1% of the world’s population and the prevalence of CD is still increasing. In China, an unseen ‘‘celiac iceberg’’, with the prevalence of CD in adults being higher than previously suggested, cannot be excluded. However, it is still lacking that awareness of CD among Chinese health professionals and food industry professionals. This review focused on the pathogenesis, clinical manifestations, diagnosis, and management of CD. We should raise the awareness of the health and societal impact of CD, develop prevention strategies to guar-antee the health and quality of life of Chinese individuals suffering from CD, and promote the development of gluten-free food in China.