食物过敏原消减研究进展

Research progress on elimination of food allergen

中文关键词:  食物过敏  食物过敏原  消除方法  机制研究方法

英文关键词:food allergy  food allergen  elimination methods  research methods on mechanism

中文摘要:

      如今食物过敏是困扰人类健康的一大重要食品安全问题, 发病率持续升高, 受到全世界的广泛关注。本文简要介绍了食物过敏及其机制, 详细分析了近五年相关文献的研究内容, 发现这五年文献数量保持稳定, 各国的研究重点仍集中于8大类主要过敏食物, 过敏原的3大类消除方法中以物理化学法的研究最为丰富。本文在总体介绍各种消除方法的同时, 详细介绍了最常用的4种物理消除方法: 热处理、辐照、超声和超高压技术。此外, 文中还介绍了消减机制的4种主要研究方法, 但如今机制研究还处于初始阶段, 尚未得出系统明确的结果, 因此相关的深入研究具有良好的前景。可以以体外模拟消化为基础, 继续研究消化片段的致敏性变化与构象变化的关系, 有针对性的实现过敏原的消除。

英文摘要:

      In recent years, food allergy is a serious food safety issue threatening human health. It has been widely concerned in the world that the incidence of food allergy continues to rise. This paper introduced food allergy and its mechanism briefly. After detailed analysis of the relevant published items in recent five years, it was found that the number of published items remained stable and the researchers still focused on 8 major categories of allergic food to study. Physical and chemical method, as one of 3 categories of elimination methods, was the most common research filed. Therefore 4 physical elimination methods, including heat treatment, irradiation, ultrasound and ultra high pressure technology, were introduced in detail. In addition, the paper also introduced 4 main research methods of the reduction mechanism. However, the mechanism research was still in the initial stage and the system has not yet come to a clear result, so the relevant in-depth study has a good prospect. Based on in vitro simulated digestion, researches of the relationship between the allergenicity change and conformation change of digestive fragments might be effective to achieve the allergen elimination in target.