关于改善维生素C加E咀嚼片黑色斑点的研究

Study on solving the problem of vitamin C and E chewable tablets turning black

中文关键词:  维生素C加E咀嚼片  黑色斑点  美拉德反应

英文关键词:Vitamin C and E chewable tablets  black spots  Maillard reaction

中文摘要:

      目的 从配方工艺的角度, 找出维生素C加E咀嚼片产生黑色斑点的根源并对其解决, 保证该产品的质量。方法 通过稳定性考察样品的送检情况, 开展原辅材料的排除性工艺试验, 小试制粒、压片和加速考察调整问题配方。结果 工艺调整后, 片剂黑色斑点现象得到了有效的改善。结论 产品配方中的维生素C与明胶发生了美拉德反应, 引起了褐变, 导致片剂产生黑色斑点。经优化后的配方工艺, 问题得到彻底解决。

英文摘要:

      Objective To find the cause of the vitamin C and E chewable tablets turning black and its solution from the point of view of the formulation process, and guarantee the quality of the product. Methods Based on the stability test results, the exemplary process test was carried out by granulating, tableting, and the stability test to adjust the formula. Results After adjusting the process, the problem of tablets turning black had been effectively improved. Conclusion The Maillard reaction of vitamin C and gelatin are produced in the product, which caused the black spots appearing on tablets. After optimization of the formulation process, the problem is solved completely.