复合解酒颗粒冲剂制备工艺优化

Optimization of preparation process of compound antialcoholism granules

中文关键词:  解酒  乙醇脱氢酶  颗粒冲剂  植物提取物  玉米肽

英文关键词:antialcoholism  alcohol dehydrogenase  granule  herb extract  corn peptide

中文摘要:

      目的 以葛根、五味子及决明子的提取物和玉米多肽为原料, 添加适当辅料, 研制复合解酒颗粒冲剂。方法 分别以乙醇脱氢酶激活率和感官评价得分为指标, 在单因素试验的基础上通过正交试验优化得出产品的最佳配方。结果 通过L9(33)正交试验优化所得植物提取物解酒配比: 葛根:五味子:决明子为3:4:4; 提取物与玉米肽的复合配比: 植物混合物:玉米肽为1:1.2, 其对乙醇脱氢酶的激活率为92.31%。通过L9(34)正交试验优化所得复合冲剂的最终配方即复合肽、麦芽糊精、白砂糖、β-环状糊精的比例为1:6:5:0.6, 得到组织状态均匀、冲调性好、口感甘甜的颗粒冲剂。结论 植物提取物与玉米肽的复合可以提高乙醇脱氢酶活性, 起到协同促进的解酒作用。通过体外测定酶活力的方法可以筛选出最佳的解酒配方, 为研制解酒产品提供了新思路。

英文摘要:

      Objective To develop a kind of compound antialcoholism granules, with corn peptides and extracts of Pueraria lobata, Schisandra chinensis and Catsia tora Linn as essential ingredients and excipients. Methods Based on single factor tests and orthogonal tests, the optimum formula which could increase the activity of alcohol dehydrogenases was found, taking alcohol dehydrogenase activation rate and sensory evaluation score as indicators. Results The research demonstrated that the proportions were as follows: Pueraria lobata : Schisandra chinensis : Catsia tora Linn was 3:4:4; herb mixture:corn peptides was 1:1.2, and the activation rate of alcohol dehydrogenases reached 92.31%. Through an orthogonal test (L9(34)), the final formula ratio of compound peptides, maltodextrin, white sugar and β-cyclodextrin was 1:6:5:0.6. Ultimately, the granules with homogeneous structural state, good solubility and acceptable taste were produced. Conclusion Herb extracts and corn peptides have a synergistic effect on antialcoholism. Measuring the activity of ADH in vitro can determine the antialcoholism formula efficiently, which is a prospective method.