燕麦麸β-葡聚糖降血糖及抗氧化作用研究

Effect of oat bran β-glucan on hypoglycemic and antioxidant

中文关键词:  燕麦麸  β-葡聚糖  降血糖  抗氧化

英文关键词:oats bran  β-glucan  hypoglycemic effect  antioxidant

中文摘要:

      目的 研究燕麦麸β-葡聚糖的降血糖和抗氧化功效。方法 将小鼠分为正常组和模型组, 模型组通过注射四氧嘧啶建立糖尿病模型。比较分析各组小鼠体重、摄食量、饮水量、血糖值、耐糖量、肝脏超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)和丙二醛(MDA)含量。结果 高剂量组对糖尿病小鼠摄食饮水量的减少和体重增加有显著影响且高剂量组小鼠血糖值降低25.39%。燕麦麸β-葡聚糖对正常小鼠的体重、饮水量、摄食量、血糖值、耐糖量没有明显的作用。与对照组比较, 模型组小鼠血糖曲线下面积、SOD、GSH-PX的活性显著提高, 体内MDA的含量显著降低。结论 燕麦麸β-葡聚糖能降低糖尿病小鼠的血糖值和提高糖尿病小鼠的抗氧化能力, 对正常小鼠没有影响。

英文摘要:

      Objective To study the effects of oat bran β-glucan on hyooglycemic and antioxidant. Methods The mice were divided into normal group and model group. The models of experimental diabetes were built by injecting Alloxan in mouse. The body weight, food intake, water intake, blood glucose levels, the glucose tolerance, superoxide dismutase (SOD), glutathione peroxidase (GSH-PX) and malondialdehyde (MDA) in the liver, and organ index of mice were analyzed. Results The high dosage group could reduce the average amount ingestion and water intake and increase the average weight of diabetic mice obviously, and the glucose levels of high dosage group were 25.39%. Oat bran β-glucan made no significant effect on normal mice’s weight, water intake, food intake, blood glucose level, and glucose tolerance. Compared with control group, model group in mice the area under blood glucose curve, SOD, and GSH-PX activity were increased significantly, and the body MDA content was decreased significantly. Conclusion The results indicate that oat bran β-glucan has no effect on normal mice but can decrease the blood glucose levels of diabetic mice and improve the antioxidant capacity of diabetic mice.