| 尹帅星,吕 冰,张 磊,李敬光,吴永宁.血清中二噁英类物质的同位素稀释-全二维气 相色谱-串联质谱法研究[J].食品安全质量检测学报,2015,6(3):992-999 |
| 血清中二噁英类物质的同位素稀释-全二维气 相色谱-串联质谱法研究 |
| Investigation of polychlorinated dibenzo-p-dioxins in serum by isotope dilution-comprehensive two dimensional gas chromatography-tandem mass spectrometry |
| 投稿时间：2015-02-03 修订日期：2015-03-21 |
| DOI： |
| 中文关键词: 全二维气相色谱-串联质谱法 同位素稀释法 多氯代二苯并二噁英和多氯代二苯并呋喃 |
| 英文关键词:comprehensive two dimensional gas chromatography-tandem mass spectrometry isotope dilution polychlorinated dibenzo-p-dioxins |
| 基金项目:国家自然科学基金项目(21361140359) |
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| Author | Institution |
| YIN Shuai-Xing | School of Food Science and Engineering, Wuhan Polytechnic University, Hubei Collaborative Innovation Center for Processing of Agricultural Products |
| LV Bing | Key Laboratory of Food Safety Risk Assessment, Ministry of Health, China National Center for Food Safety Risk Assessment |
| ZHANG Lei | Key Laboratory of Food Safety Risk Assessment,Ministry of Health, China national Center For Food Satety Risk Aeeseement |
| LI Jing-Guang | Key Laboratory of Food Safety Risk Assessment,Ministry of Health, China national Center For Food Satety Risk Aeeseement |
| WU Yong-Ning | Key Laboratory of Food Safety Risk Assessment,Ministry of Health, China national Center For Food Satety Risk Aeeseement |
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| 中文摘要: |
| 目的 建立高灵敏度和高选择性的全二维气相色谱-串联质谱法(GC×GC-MS/MS)测定17种多氯代二苯并二噁英和多氯代二苯并呋喃(PCDD/Fs)同系物的痕量分析方法。方法 将牛血清样品经过加速溶剂萃取, 全自动净化仪净化后, 通过配备DB-5MS和BPX-50柱全二维气相色谱-串联质谱进行样品分析。结果 17种PCDD/Fs同系物的标准曲线在范围内显示良好线性(R2 > 0.99) 。方法的检出限为0.1~0.8 pg/g。结论 本方法满足血清样品中PCDD/Fs 的痕量分析需求。 |
| 英文摘要: |
| Objective A method based on comprehensive two dimensional gas chromatography-tandem mass spectrometry (GC×GC-MS/MS) was developed for the determination of polychlorinated dibenzo-p-dioxins (PCDD/Fs). Methods Bovine serum were extracted by accelerated solvent extraction and purified by fluid management system. Then the target congeners were analysed by comprehensive two dimensional gas chromatography-tandem mass spectrometry with DB-5MSand BPX-50. Results The calibration curves of 17th target compounds showed a good linearity (R2>0.99), the limits of detection of the method were 0.1~0.8 pg/g. Conclusion With high selectivity and sensitivity, the method can apply to analyze the PCDD/Fs in bovine serum. |
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