猪戊型肝炎病毒检测技术的研究进展

Progress in the detection methodology of swine hepatitis E virus

中文关键词:  猪戊型肝炎病毒  人畜共患病  检测技术

英文关键词:swine hepatitis E virus  zoonosis  detection technology

中文摘要:

      猪戊型肝炎是一种新的人畜共患病, 其病原戊型肝炎病毒(hepatitis E virus, HEV)是无囊膜的RNA病毒, 主要通过消化道进行传播。研究发现, 世界上许多国家的猪群中普遍存在HEV抗体及猪戊型肝炎病毒RNA携带。与患病猪群密切接触、食用未煮熟的猪肉或猪肉制品、被污染的水源及水产品, 这些因素都可增加戊型肝炎的患病风险。猪作为戊型肝炎病毒的宿主, 不仅对公共卫生和食品安全构成威胁, 同时对人类戊型肝炎流行病学有很大的影响。本文简要介绍了HEV的病原学以及抗原抗体检测方法, 包括血清学、免疫学及分子生物学方法等, 并对国内外开展的戊型肝炎检测技术的研究进展进行综述。

英文摘要:

      Swine hepatitis E is a new kind of zoonosis, with the pathogen of hepatitis E virus (HEV). Non-enveloped hepatitis E virus has a single stranded positive-sense RNA genome. Fecal-oral transmission is the usual route of hepatitis E. The studies have shown that the existing of HEV antibodies and swine HEV RNA among pigs through the world. It will increase the risk of infecting hepatitis E when people come into contact with sick pigs, or eating undercooked pork and products, contaminated water and fishery products. Pigs as the host of HEV, not only pose a threat to public health and food safety, but also greatly influence the epidemiology of human hepatitis E. The etiology and detection methodology of HEV were introduced in this paper, including serology, immunology and molecular biology method. The progress in research of detection of HEV was reviewed in detail, including the detection of antigen and antibody.