液质联用技术在生物毒素食品安全检测分析中的应用

Applications of liquid chromatograhpy coupled with mass spectrometry in the detection of biological toxin in food safety testing

中文关键词:  真菌毒素  贝类毒素  河鲀鱼毒素  西加鱼毒素  液质联用技术  样品处理

英文关键词:mycotoxin  shellfish toxin  tetrodotoxin  ciguatoxin  liquid chromatography couple to mass spectrometry  sample processing

中文摘要:

      生物毒素是自然界一种重要的生命现象, 是人们探讨生命科学奥秘和开发新药的重要工具和物质基础, 也是食品安全领域的重点防治对象。真菌毒素和海洋生物毒素是与食品安全相关的两类生物毒素, 二者均具有毒性强、污染面广的特点, 对人类健康具有极大的危害。在生物毒素众多分析检测手段中, 液质联用技术因灵敏、高效等特点而被广泛应用。本文以液质联用技术为切入点, 综述了该技术用于生物毒素食品安全检测分析的研究与应用进展, 同时对相关的样品处理技术研究也进行了概要介绍。

英文摘要:

      Biological toxin is a kind of important life phenomenon in nature, an important tool and the material basis to explore the secrets of life science and development of new drugs, and is also a key preventive treatment object in the field of food safety. Mycotoxin and marine biotoxins which are two kinds of natural toxic substances associated with food safety, have the characteristics of strong toxicity and pollute widely and a great harm to human health. Among the detection means of mycotoxin and marine biotoxin, the technique of liquid chromatography coupled with mass spectrometry (LC-MS) is widely used for its sensitive and efficient characteristics. Based on the LC-MS technique as a breakthrough point, its application in biological toxins related to food safety testing analysis in recent years were reviewed, as well as the related sample processing technology progress.