纳米银的毒理学研究进展

Research progress on toxicology of nano silver

中文关键词:  纳米银  亚细胞毒性  遗传毒性  作用机制

英文关键词:silver nanoparticles  cytotoxicity  subcellular toxicity  genotoxicity  mechanism

中文摘要:

      纳米银具有广谱、高效的抗菌性, 能够均匀分散在不同类型的聚合物中, 在食品保鲜领域具有很大的应用价值, 但其安全问题也备受关注。纳米银能够透过生物膜上的孔隙进入细胞或者线粒体、细胞核等细胞器内, 与蛋白质等生物大分子发生结合, 影响细胞的功能。本文从细胞毒性、亚细胞毒性、遗传毒性等方面综述了纳米银的生物安全性, 并对细胞内纳米银与生物大分子相互作用进行探讨, 为在分子水平上系统研究纳米银的作用机制以及纳米银的毒理研究提供帮助。

英文摘要:

      Silver nanoparticles, which is broad-spectrum and efficient in antimicrobial, can be uniformly dispersed in different types of polymers and has a great application value in the field of food preservation, however, it is high-profile for its security problem. Silver nanoparticles can enter the cell or the mitochondria, nucleus and other organelles through the membrane, and will affect cell function by combining with biomacromolecules such as protein. This paper discusses the biological safety of silver nanoparticles from different angles, such as cell toxicity, subcellular toxicity and genetic toxicity, especially discusses the interactions of silver nanoparticle with biomacromolecules in cell, which offers help for researching the mechanism of action of silver nanoparticles at the molecular level and the research of toxicology of silver nanoparticles .