全脂羊乳粉中塑化剂的暴露量调查及安全评估

Safety assessment and investigation on exposure of phthalate esters in whole goat milk powder

中文关键词:  全脂羊乳粉  塑化剂  污染状况  暴露量  Monte Carlo模拟

英文关键词:whole goat milk powder  phthalate esters  contamination  exposure evaluation  Monte Carlo simulation

中文摘要:

      目的 调查国内有代表性的羊乳粉加工企业生产的乳粉中塑化剂的种类和含量, 并评估羊乳粉中塑化剂的暴露量情况, 为安全性评价提供参考。方法 通过Monte Carlo模拟对不同年龄段的婴幼儿通过乳基粉对塑化剂的膳食暴露情况进行非参数概率评估, 按照美国环境保护署(EPA)提出的经口摄入参考剂量(reference dose, RfD), 对塑化剂膳食暴露引发的健康风险进行评价。结果 Ⅰ、Ⅱ、Ⅲ段龄3组婴幼儿对邻苯二甲酸二(2-乙基)己酯(DEHP)摄入量的平均值(90% Confidence Interval)的致癌风险分别为1.56×10-5、2.16×10-5、1.33×10-5 a-1, 均在EPA推荐的最大可接受值1.0×10-4 a-1范围之内。以高百分位(P99)计算来看, 3组婴幼儿的邻苯二甲酸二异丁酯(DIBP)、DEHP、邻苯二甲酸二环己酯(DCHP)、邻苯二甲酸二丁酯(DBP)的健康风险值均小于1, 在风险控制标准之下。结论 以羊乳粉作为生产婴幼儿配方乳粉的基料是安全的。

英文摘要:

      Objective The concentration of phthalate esters in the base powder from different representative enterprises in China were analyzed, to evaluate the safety of phthalate esters exposure, and to provide the reference for prevention and industry supervision. Methods Dietary intake of phthalate esters from goat milk powder in different ages of infants was simulated by Monte Carlo simulation, and health risk associated with phthalate esters intake was evaluated by applying a reference dose (reference dosed, RfD) developed by Environmental Protection Agency of USA. Results Simulated DEHP intake (90% confidence interval) in three groups of infants, the carcinogenic risk values of 0~6 month, 6~12 month, 1~3 year-old was 1.56×10-5, 2.16×10-5, 1.33×10-5 a-1, respectively. Risk values caused by DEHP are all below the standard recommended (1.0×10-4 a-1) by US Environmental Protection Agency. The risk values of three groups of infants caused by DEHP, DCHP, DIBP, DBP are all lower than 1 at the 99th percentile, and they are under the risk control standard. Conclusion It is safe to use goat milk powder to produce infant formula powder.