波尔多液的亚慢性毒性及其主要影响因素

Sub-chronic toxicity studies on bordeaux mixture affected by copper sulfate

中文关键词:  波尔多液  硫酸铜  亚慢性毒性

英文关键词:bordeaux mixture  copper sulfate  sub-chronic toxicity

中文摘要:

      目的 评价波尔多液的亚慢性毒性并研究影响其亚慢性毒性的主要因素。方法 通过SD大鼠30 d喂养实验, 分别以波尔多液和硫酸铜为受试物, 观察大鼠生理状况, 记录其体重和进食量, 并对各组实验动物血液学指标、血液生化学指标以及脏器病理学指标进行了检测。结果 各组大鼠生长良好, 生理状况正常, 各项指标与对照组相比无明显异常。故波尔多液和硫酸铜无明显亚慢性毒性作用, 波尔多液的最大无作用剂量超过50 mg/kg BW, 作为农药较为安全可靠。结论 波尔多液主要成分硫酸铜最大无作用剂量超过125 mg/kg BW, 对波尔多液的亚慢性毒性无不良影响。

英文摘要:

      Objective To evaluate the sub-chronic toxicity of bordeaux mixture and study copper sulfate’s impact on bordeaux mixture’s sub-chronic toxicity. Methods SD rats were fed with bordeaux mixture and copper sulfate for 30 d, respectively. The physiological conditions of rats were observed, body weight and food intake were record, and hematological, biochemical parameters and organ pathology were tested. Results Rats grew well, and physiological conditions were normal. The indicators compared with the control group showed no abnormalities. Therefore bordeaux mixture and copper sulfate had no significant sub-chronic toxicity. The observed maximal non-effect dosage of bordeaux mixture was over 50 mg/kg BW and bordeaux mixture was secure as a pesticide. Conclusion The observed maximal non- effect dosage of copper sulfate, the main component of bordeaux mixture is over 125 mg/kg BW and copper sulfate has no adverse effects on bordeaux mixture’s sub-chronic toxicity.