乳酸菌作为粘膜重组疫苗呈递载体的研究进展

Advances in the field of lactic acid bacteria as delivery vehicles for mucosal recombinant vaccines

中文关键词:  重组乳酸菌  呈递载体  黏膜疫苗  

英文关键词:recombinant lactic acid bacteria  delivery vehicle  mucosal vaccine

中文摘要:

      乳酸菌是对人和动物具有多种益生功能的食品级微生物, 被广泛地应用于食品、医药、生物技术等领域。乳酸菌的安全益生特性及乳酸菌基因表达系统研究取得的重大进展, 使得重组乳酸菌黏膜疫苗成为研究的热点。乳酸菌作为黏膜免疫的蛋白呈递载体, 可诱导机体产生有效的免疫反应和免疫耐受, 具有巨大的发展潜力。

英文摘要:

      Lactic acid bacteria (LAB) are food-grade microorganisms, which exert various probiotic roles on the host, and have been widely applied in the fields of food, medicine, and biotechnology. The safety status and probiotic properties of LAB, as well as great strides in the development of LAB gene expression systems render the study of mucosal recombinant LAB vaccines a compelling research area. The use of LAB as protein delivery vectors for mucosal immunization, can effectively elicit both immune response and immune tolerance, and has great potential.