丙烯酰胺生殖和发育毒性及其生物标志物的研究进展

Review of the biomarker research of acrylamide reproductive and developmental toxicity

中文关键词:  丙烯酰胺  生殖毒性  发育毒性  生物标志物

英文关键词:acrylamide  reproductive toxicity  developmental toxicity  biomarker

中文摘要:

      丙烯酰胺(acrylamide, AA)是含淀粉类食品经过120℃以上高温加热后产生的, 有研究表明AA对机体有生殖毒性、发育毒性、神经毒性和基因毒性等, 尤其是AA的生殖毒性和发育毒性逐渐引起了人们的广泛关注。在AA的生殖毒性和发育毒性研究中, 任何反映生殖系统损伤的指标均可作为AA生殖毒性的生物标志物; 同样, 所有能反应发育毒性终点的指标均可作为AA发育毒性的生物标志物。随着越来越多的生物标志物的确定, 其在安全性评价中也将发挥重要的作用。因此, 生物标志物的研究对综合评价AA的生殖毒性和发育毒性有非常重要的意义。本文综述了国内外对AA的生殖毒性和发育毒性生物标志物的研究进展, 为AA这两种毒性评价指标的选择提供参考。

英文摘要:

      Acrylamide (AA) is primarily generated in starchy food which heated up to 120 ℃. Researches showed that AA had reproductive toxicity, developmental toxicity, neurotoxicity and genetic toxicity to the body. Especially, the reproductive and developmental toxicity of AA attracted a great of attentions gradually. In the research of reproductive toxicity and developmental toxicity of AA, any indexes reflected reproductive system damage could be used as biomarkers of AA reproductive toxicity. As the same, any indexes reflected developmental system damage could also be used as biomarkers of AA developmental toxicity. As more and more biomarkers have been determined, they will play an important role in the risk assessment. Therefore, the evaluation of biomarker has very important significance in comprehensive research of AA reproductive and developmental toxicity. This paper reviewed the biomarker of reproductive and developmental toxicity of AA, and described them from various perspectives.