n-3多不饱和脂肪酸、内质网应激与非酒精性脂肪肝病的研究进展

Research progress of fatty acids and the endoplasmic reticulum stress in non-alcoholic fatty liver disease

中文关键词:  n-3多不饱和脂肪酸  脂代谢  内质网应激  非酒精性脂肪肝病

英文关键词:n-3 polyunsaturated fatty acids  lipid metabolism  endoplasmic reticulum stress (ERS)  non-alcoholic fatty liver disease (NAFLD)

中文摘要:

      非酒精性脂肪性肝病(nonalcoholic fatty liver disease, NAFLD)已逐渐成为一个全球性健康问题, 但其发病的具体机制不甚明朗。内质网是细胞内蛋白质加工、脂质合成和钙储存的主要场所, 内质网结构和功能的失常所致的内质网应激(endoplasmic reticulum stress, ERS)对脂代谢和细胞功能具有重要调控作用, 可能是NAFLD的发生和发展的重要机制。近来大量研究显示, 脂类中特定的脂质负荷(饱和脂肪酸、胆固醇)可能是诱导ERS导致NAFLD重要原因, 而另一方面, n-3多不饱和脂肪酸(n-3 polyunsaturated fatty acids, n-3 PUFA)的摄入量却与NAFLD患病率呈负相关。本文就脂肪酸与内质网应激及其与NAFLD的联系作一综述, 进一步探讨n-3多不饱和脂肪酸防治NAFLD的机制。

英文摘要:

      Non-alcoholic fatty liver disease (NAFLD) is a worldwide public health problem. The underlying causes of NAFLD are unclear. Endoplasmic reticulum is the main site of protein processing, lipid synthesis and storage of calcium. Disruption of Endoplasmic reticulum homeostasis, which often induces endoplasmic reticulum stress (ERS), plays an important regulatory role in lipid metabolism and cell function. Recent evi-dence implicated the ERS in both the development of steatosis and progression to nonalcoholic steatohepatitis. In the current review, we discussed the involvement of different fatty acids in the pathogenesis of NAFLD with particular emphasis on the role of ERS, explored the mechanism of n-3 polyunsaturated fatty acids in the prevention and treatment of NAFLD.