吡咯喹啉醌的保健功能及检测方法研究进展

Research progress on health care functions and detection methods of pyrroloquinoline quinone

中文关键词:  吡罗喹啉醌  保健功能  抗氧化  增强免疫力  高效液相色谱法

英文关键词:pyrroloquinoline quinone  health care function  antioxidant  boost immunity  high performance liquid chromatography

中文摘要:

      吡咯喹啉醌是一种具有氧化还原特性的水溶性醌类化合物, 可通过参与体内氧化还原等过程发挥多种生物学功能。目前, 该物质已被多个国家列入膳食补充剂、功能性食品原料目录中。在我国, 吡咯喹啉醌已被列入新食品原料, 允许限量添加于饮料类食品中。随着研究的继续深入, 其在保健食品领域的应用前景将愈发广阔。本文梳理了近年来国内外吡咯喹啉醌相关的生物学功能研究、安全毒理学研究、检测技术研究, 并将研究中的生物学功能按照我国允许保健食品声称的保健功能目录进行分类, 对其生物学功能作用机制、功能评价指标、安全性、检测技术等领域的研究方向进行展望, 以期为吡咯喹啉醌相关功能产品的开发, 以吡咯喹啉醌为原料的保健食品的注册、研发、审评、监管提供一定的技术参考。

英文摘要:

      Pyrroloquinoline quinone is a redox-active quinone molecule which is soluble in water. It exerts various biological functions by participating processes such as oxidation-reduction in the body and has been successively included in the lists of dietary supplements and functional food ingredients in many countries. Pyrroloquinoline quinone has been approved as a novel food ingredient, with permission for limited addition to beverage products in China. With the continuous deepening of research, it has broad application prospects in the field of health food. This article reviewed the recent research on the biological functions, safety toxicology and detection technologies of pyrroloquinoline quinone, classified the biological functions according to the catalogue of health functions permitted to be claimed by health food, provided insights into the research trends of biological functional mechanisms, functional evaluation indicators, safety and detection technologies, aiming to provide scientific evidence for the development of pyrroloquinoline quinone-related functional products, as well as for the registration, development, evaluation and supervision of health food which used pyrroloquinoline quinone as raw material.