青霉素类抗生素降解产物检测技术研究进展

Research progress on detection techniques for degradation products of penicillin antibiotics

中文关键词:  青霉素  降解产物  青霉噻唑酸

英文关键词:penicillin  degradation products  penicilloic acid

中文摘要:

      青霉素类抗生素被广泛应用于动植物疾病防控领域, 但由于使用不规范甚至违规使用, 导致食品中青霉素的残留。青霉素的分子结构不稳定, 不同条件下会产生不同程度的降解, 其降解产物如青霉噻唑酸等是其致敏性和细胞毒性的主要因素。且一旦发生降解, 原来针对青霉素原药的检测技术将无法准确反映实际情况。目前, 国内外对于青霉素类抗生素降解产物在食品安全方面的潜在风险尚未给予足够重视。本文总结了青霉素类抗生素在不同条件下的降解过程; 重点综述了高效液相色谱法、液相色谱-串联质谱法、免疫分析法以及表面增强拉曼光谱法在青霉素类抗生素降解产物检测中的具体应用; 同时分析了各类方法所具备的适用性特征以及存在的局限性, 以期提高对青霉素类抗生素降解产物残留所引发的食品安全问题的重视, 并为相关检测技术的进一步研究与发展提供参考。

英文摘要:

      Penicillin antibiotics are widely used in the field of animal and plant disease prevention and control. However, due to improper or even illegal use, there are residues of penicillin antibiotics in food. The molecular structure of penicillin is unstable and undergoes varying degrees of degradation under different conditions. The degradation products, such as penicilloic acid, are the primary contributors to its allergenicity and cytotoxicity. And once penicillin degrades, conventional detection technologies for it will not accurately reflect the actual situation. At present, the potential risks of degradation products of penicillin antibiotics in food safety have not been given sufficient attention both domestically and internationally. This article summarized the degradation processes of penicillin antibiotics under different conditions, summarized the specific applications of high performance liquid chromatography, liquid chromatography-tandem mass spectrometry, immunoassay and surface-enhanced Raman spectroscopy in the detection of degradation products of penicillin antibiotics. Additionally, this paper analyzed the applicability characteristics and limitations of these methods to raise awareness of food safety issues caused by degradation products of penicillin antibiotics and provide references for further research and development of related detection technologies.