手性三唑类农药分离分析及立体选择性行为研究进展

Progress in separation analysis and stereoselectivity behavior of chiral triazole pesticides

中文关键词:  手性农药  三唑类农药  对映体  残留  分离分析

英文关键词:chiral pesticides  triazole pesticides  enantiomer  residual  separation analysis  stereoselectivity

中文摘要:

      手性三唑类杀菌剂一般含有1或2个手性中心, 存在2~4个对映体, 是目前用于病虫害防治使用最广泛的杀菌剂。现有大量实验表明, 手性三唑类杀菌剂对映体具有选择性降解行为, 且对映体毒性活性存在差异, 为更准确地评估手性农药的风险, 亟需针对手性单体进行研究, 但手性农药对映体间因有相同的理化性质, 难以用常规手段进行分离分析。因此, 手性分离检测方法一直是领域研究的重点和热点, 朝着快速、高效、精准的领域发展。本文通过对手性三唑类农药分离分析及立体选择性行为研究进展进行综述, 旨在明确手性农药在环境及植株体内的立体选择性行为, 为手性农药高效低风险的使用提供数据支撑。

英文摘要:

      Chiral triazole fungicides generally contain 1 or 2 chiral centers and 2–4 enantiomers, making them the most extensively employed fungicides in the realm of disease and pest management. Numerous existing experiments have demonstrated that chiral triazole fungicides exhibit selective degradation behavior in their enantiomers, and there are differences in their toxic activity. Therefore, the study of chiral monomers is crucial for the accurately evaluation for the risk. Nevertheless, due to the same physical and chemical properties between enantiomers of chiral pesticides, it is difficult to separate and analyze them using conventional methods. Hence, the study field has consistently prioritized and emphasized chiral separation and detection techniques, with a particular emphasis on their rapidity, efficiency, and precision. This article reviewed the advancement in the field of separation analysis and stereoselective behavior of chiral triazole pesticides. It aims to elucidate the stereoselective behavior of chiral pesticides in the environment and in plants, and to provide empirical evidence to support for the effective and safe utilization of chiral pesticides.