基于氧化应激对手性三唑类杀菌剂诱导斑马鱼毒性效应的研究进展

Advances in oxidative stress-based adversarial triazole fungicide induced toxic effects in Danio rerio

中文关键词:  三唑类杀菌剂  手性  斑马鱼  对映异构体  氧化应激

英文关键词:triazole fungicides  chirality  Danio rerio  enantiomer  oxidative stress

中文摘要:

      三唑类杀菌剂一般具有一个或多个手性中心, 因在环境及食品加工过程中具有立体选择性行为, 一直是研究的热点与重点。三唑类杀菌剂因大量使用不可避免残留在水体及食品中, 随着食物链进入到人体内, 因此, 基于模式生物斑马鱼的毒理学评价对三唑类杀菌剂评估具有重要意义。本文对近年来手性三唑类杀菌剂诱导斑马鱼毒性效应进行综述, 发现其毒性效应大多与氧化应激调控有关, 但从手性对映体角度对三唑类杀菌剂对斑马鱼的影响及分子机制阐述尚不清晰。围绕氧化应激通路、线粒体氧化磷酸化及抗氧化酶活性改变等方面, 探索三唑类杀菌剂的选择性毒性机制, 可为食品中农药类危害物毒性风险评估的控制提供基础数据与研究思路。

英文摘要:

      Triazole fungicides generally have one or more chiral centers and have been a hot spot and focus of research because of their stereoselective behavior in the environment and during food processing. Due to the heavy use, triazole fungicides are inevitably left in water and food and reach human body via the food chain; therefore, toxicological evaluation using Danio rerio as a model organism is essential for triazole fungicide assessment. This paper reviewed the role of chiral triazole fungicides in inducing toxicity in Danio rerio in recent years and found that majority of their toxic effects were related to oxidative stress regulation. However, the effects and molecular mechanisms of triazole fungicides on Danio rerio from a chiral enantiomeric perspective were not clearly elucidated. Focusing on oxidative stress pathway, mitochondrial oxidative phosphorylation and changes in antioxidant enzyme activity, exploring the selective toxicity mechanism of triazole fungicides can provide basic data and research ideas for the control of toxicity risk assessment of pesticide hazards in food.