草莓中氟啶虫胺腈及其代谢物降解规律及风险评估

Degradation and risk assessment of sulfoxaflor and its metabolites in strawberry

中文关键词:  氟啶虫胺腈  代谢物  消解动态  超高效液相色谱-串联质谱法  草莓

英文关键词:sulfoxaflor  metabolites  degradation dynamics  ultra performance liquid chromatography-tandem mass spectrometry  strawberry

中文摘要:

      目的 探究草莓生长过程中氟啶虫胺腈及其代谢物的残留降解变化规律以及膳食暴露风险。方法 利用超高效液相色谱-串联质谱法建立了草莓中氟啶虫胺腈及其代谢物的高灵敏度快速测定方法; 通过田间试验, 明确氟啶虫胺腈在草莓中的残留消解规律, 并进行膳食风险评估。结果 在正离子多反应监测模式下, 氟啶虫胺腈及其代谢物基质和溶液匹配标准曲线在0.1~100.0 ng/mL的浓度范围内线性关系良好, 最低检出限为0.01 μg/kg, 最低定量限为0.02 μg/kg, 不同添加浓度下回收率范围在88.16%~104.14%, 相对标准偏差小于等于9.18%, 符合痕量检测的要求; 田间试验结果表明氟啶虫胺腈在草莓中经过代谢会产生X11719474和X11721061 2种代谢产物, 且消解规律符合一级动力学方程, 半衰期为14.75 d; 膳食风险评估结果表明, 氟啶虫胺腈在草莓中膳食暴露风险较低。结论 以10 g/亩剂量在温室草莓上使用50%氟啶虫胺腈水分散粒剂, 氟啶虫胺腈及其代谢物X11719474和X11721061无显著膳食暴露风险。

英文摘要:

      Objective To explore the residual degradation dynamics and risks of sulfoxaflor and its metabolites in strawberry. Methods A highly sensitive and rapid method for the determination of sulfoxaflor and its metabolites in strawberry was established by ultra performance liquid chromatography-tandem mass spectrometry. The field experiment was conducted to clarify the residual digestion rule of sulfoxaflor in strawberry and evaluated the dietary risk. Results The calibration curves of sulfoxaflor and its metabolites in matrix and solution matching exhibited a good linear response in the range of 0.1?100.0 ng/mL, the lowest limit of detection was 0.01 μg/kg, and the lowest limit of quantification was 0.02 μg/kg. The recovery was within the range of 88.16%–104.14% at different concentrations, and the relative standard deviation was less than or equal to 9.18%, which met the requirements of trace detection. The field trial results showed that after metabolism, sulfoxaflor could produce X11719474 and X11721061 metabolites, and the digestion rule conformed to the first-order kinetic equation, with the half-life of 14.75 d. The results of dietary risk assessment indicated that the dietary exposure risk of sulfoxaflor in strawberry was low. Conclusion Using 50% sulfoxaflor water dispersible granules on strawberry in greenhouse at a dose of 10 g/mu, sulfoxaflor and its metabolites X11719474 and X11721061 have no significant dietary exposure risk.