高效液相色谱法测定化妆品中苯氧乙醇含量的不确定度评定

Uncertainty evaluation in determination of 2-phenoxyethanol in cosmetic by high performance liquid chromatography

中文关键词:  不确定度  苯氧乙醇  化妆品  防腐剂  高相液相色谱法

英文关键词:uncertainty  2-phenoxyethanol  cosmetic  preservatives  high performance liquid chromatography

中文摘要:

      目的 评定《化妆品中防腐剂的检测方法(征求意见稿)》中高效液相色谱法测定化妆品中苯氧乙醇含量的不确定度。方法 依据国家计量技术规范JJF 1059.1-2012《测量不确定度评定与表示》对苯氧乙醇测定中的不确定度来源进行分析。通过建立数学模型量化不确定度分量, 计算合成不确定度和扩展不确定度。结果 当样品中苯氧乙醇的含量为0.439%时, 扩展不确定度为0.016%, 苯氧乙醇含量表示为0.439%? 0.016%。结论 该方法测量化妆品中苯氧乙醇含量的不确定度总体较小, 方法相对准确可靠。此次评定的不确定度主要来源为重复性测量、标准曲线配制和样品定容3个方面。

英文摘要:

      Objective To evaluate the uncertainty of determination of 2-phenoxyethanol in cosmetic using high performance liquid chromatography according to “Method for the detection of preservatives in cosmetics (draft for comments)”. Methods The sources of uncertainty in determination of 2-phenoxyethanol were analyzed according to the national measurement technical specification JJF 1059.21-2012 Evaluation and expression of uncertainty in measurement. The combined uncertainty and extended uncertainty were calculated by establishing mathematical model. Results When the 2-phenoxyethanol content in the sample was 0.439%, the expanded uncertainty was 0.016%, and the 2-phenoxyethanol content was expressed as 0.439%?0.016%. Conclusion The uncertainty of determination of 2-phenoxyethanol in cosmetic is relatively small, and the method is accurate and reliable. The main sources of uncertainty are from the repeatability of sample measurement, standard solution preparation and sample volume determination.