茶色素对高渗葡萄糖抑制坐骨神经的恢复作用

Recovery of tea pigment on inhibiting the sciatic nerve by hypertonic glucose solution

中文关键词:  茶色素  高渗葡萄糖  动作电位  坐骨神经

英文关键词:tea pigment  hypertonic glucose  action potential  sciatic nerve

中文摘要:

      目的 研究20%茶色素(tea pigment, TP)对高渗葡萄糖溶液(hypertonic glucose solution, GS)损伤蟾蜍坐骨神经后的恢复作用。方法 24只蟾蜍随机分为任氏液对照组、GS组和20% TP干预组。应用生物机能实验系统测定蟾蜍坐骨神经干的动作电位并进行分析研究。结果 5% GS和10% GS均使神经干动作电位传导速度和振幅下降(P<0.05), 5% GS组和10% GS组的动作电位传导速度在10 min内呈先上升后下降趋势, 但10 min时5% GS组的传导速度仍高于10% GS组(P<0.05)。经20% TP干预后神经干动作电位振幅和传导速度上升(P<0.05)。结论 5% GS和10% GS均对神经干造成损伤, TP能拮抗GS对神经传导速度和振幅的抑制作用。

英文摘要:

      Objective Toresearch the recovery of 20% tea pigment (TP) on the inhibiting of sciatic nerve of toad by the hypertonic glucose solution (GS). Methods Twenty-four toads were randomly divided into 3 groups: the ringer’s solution group, GS group and 20% TP group. The action potential of the sciatic nerve trunk of toad was measured and analyzed by biological function experiment system.Results Both 5% GS and 10% GS decreased the conduction velocity and amplitude of the neural stem action potential (P<0.05).The action potential conduction velocity of the 5% GS group and 10% GS group were first increased and then decreased within10 min, but the conduction velocity of 5% GS group at 10 min was still higher than that of 10% GS group (P<0.05).The amplitude and conduction velocity of the neural stem action potential increased after 20% TP intervention (P<0.05). Conclusion Both 5% GS and 10% GS damage the nerve stem, and TP can antagonize the inhibitory effect of GS on nerve conduction velocity and amplitude.