牛乳β-乳球蛋白过敏原表位及其潜在应用

Epitopes on bovine β-lactoglobulin and its potential application

中文关键词:  牛乳过敏  表位  β-乳球蛋白

英文关键词:milk allergy  epitope  β-lactoglobulin

中文摘要:

      过敏原表位是过敏原直接参与免疫反应的物质基础, 也是导致过敏反应的“元凶”。牛乳β-乳球蛋白是lipocalin家族的代表和常用模式蛋白, 它的表位信息比较完整, 拥有7个人血清IgE和6个IgG的线性表位、3个IgE结合的构象性表位以及7个T细胞表位。另外, 它的动物源血清IgE、IgG和T细胞表位也在不断被发现。牛乳β-乳球蛋白的表位信息为基于表位的应用提供了重要的支撑, 它们的应用主要涉及到预测食物过敏原的致敏性, 食物过敏的交叉反应, 食物过敏的诊断, 食物过敏的免疫治疗以及食物过敏原的检测等5个方面。

英文摘要:

      Epitopes is the binding sits between allergen and the relevant antibody, and it is the triggering element of immune reaction. Bovine β-lactoglobulin belongs to lipocalin family and is one of the model proteins. It was found that 7 IgE binding and 6 IgE binding linear epitopes, 3 IgE binding conformational epitopes and 7 T cells binding epitopes existed in milk allergy patients, and the binding epitopes of other animal resource were also reported. The epitopes information plays a very important role in the application based on epitopes, and the application includes the prediction of food allergen allergenicity, cross-reactivity of food allergen, diagnosis of food allergy, immunotherapy of food allergy and analysis of food allergen.