渤海湾滨州海域海产品中全氟及多氟烷基化合物特征分布及膳食风险评估

Distribution characteristics and dietary risk assessment of per- and polyfluoroalkyl substances in the seafood of Bohai Bay Binzhou Area

中文关键词:  全氟及多氟烷基化合物  海产品  污染特征  种类差异  安全风险评价

英文关键词:per- and polyfluoroalkyl substances  seafood  contamination characteristics  species variation  risk assessment

中文摘要:

      目的 探究渤海湾滨州海域海产品中全氟及多氟烷基化合物(per- and polyfluoroalkyl substances, PFASs)的污染水平和膳食风险。方法 本研究采集了109份海产品样本, 构建超高效液相色谱-串联质谱法(ultra performance liquid chromatography-tandem mass spectrometry, UPLC-MS/MS)分析方法, 对23种PFASs开展定量检测, 并基于危害指数(hazard ratios, HR)模型评估人群通过海产品摄入PFASs的健康风险。结果 在海产品中检测到9种PFASs, 其中全氟辛酸(perfluorooctanoic acid, PFOA)的检出率达100%, 其质量浓度占比82.2%, 远高于其他PFASs。进一步分析显示, PFASs污染水平呈现显著的组分差异与品种分布特征: PFOA为双壳贝类与三疣梭子蟹中的主要污染组分, 全氟十三烷酸(perfluorotridecanoic acid, PFTrDA)在南美白对虾中总含量占比最高, 全氟辛烷磺酸(perfluorooctane sulfonic acid, PFOS)在虾蛄体内含量最高。PFOA在三疣梭子蟹不同组织中的分布存在显著差异, 蟹膏中的富集程度明显高于其他组织。通过膳食暴露风险评估进一步发现, PFOA与PFOS的HR值均小于1。结论 PFOA为滨州市海产品中PFASs的首要污染物。PFASs在不同海产品中的富集具有物种特异性, 三疣梭子蟹蓄积的总PFASs含量最高, 且主要富集于蟹膏部位。暂未发现通过食用海产品摄入PFOA和PFOS造成人类健康风险的证据。

英文摘要:

      Objective To investigate the contamination levels and dietary risks of per- and polyfluoroalkyl substances (PFASs) in seafood products from Binzhou City. Methods A total of 109 seafood samples were collected. A ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was established for quantitative detection of 23 kinds of PFASs. Population health risks from seafood-derived PFASs intake were assessed using hazard ratio (HR) models. Results The 9 kinds of PFASs were detected in seafood, with perfluorooctanoic acid (PFOA) exhibiting a detection rate of 100% and accounting for 82.2% of total mass concentration—significantly higher than other PFASs. Further analysis revealed significant compositional differences and species-specific distribution patterns in PFASs contamination levels: PFOA was the predominant contaminant in bivalve mollusks and portunus trituberculatus; perfluorotridecanoic acid (PFTrDA) accounted for the highest proportion of total PFASs in Litopenaeus vannamei shrimp; and perfluorooctane sulfonic acid (PFOS) exhibited the highest content in mantis shrimp. PFOA distribution varied significantly across different tissues of the portunus trituberculatus, with apparently higher accumulation in crab roe than in other tissues. Dietary exposure risk assessment further revealed that both PFOA and PFOS’ HR was below 1. Conclusion PFOA is the primary PFASs contaminant in seafood from Binzhou City. PFASs accumulation exhibits species specificity across seafood, with portunus trituberculatus displaying the highest total PFASs content, primarily concentrated in crab cream. No evidence of human health risks from PFOA and PFOS intake via seafood consumption has been identified.